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You want another plural of anecdote = data posting?

I have twins. Both vaccinated, one has Asperger Syndrome, on the Autism Spectrum. Figure that one out.>>>>

Here’s some more anecdote… my youngest child is autistic…and unvaccinated.

It wasn’t the vaccination people. While I do have a healthy (pun intended) skepticism for Big Pharma, vaccinations are not the cause here.>>>>

You’re absolutely right. If vaccinations were the cause of autism, then someone will have to explain why my youngest son is autistic even though he never received any vaccines. (As an aside…he also had asthma as a baby and toddler, but seems to have outgrown it with age.)

Hey, lookee here…

Prenatal exposure to acetaminophen and respiratory symptoms in the first year of life.Persky V, Piorkowski J, Hernandez E, Chavez N, Wagner-Cassanova C, Vergara C, Pelzel D, Enriquez R, Gutierrez S, Busso A.

Division of Epidemiology and Biostatistics, The University of Illinois, Chicago School of Public Health, Chicago, Illinois 60612, USA.

BACKGROUND: Prevalence of asthma in developed countries increased between the 1970s and the 1990s. One factor that might contribute to the trends in asthma is the increased use of acetaminophen vs aspirin in children and pregnant women. OBJECTIVE: To examine relationships between in utero exposure to acetaminophen and incidence of respiratory symptoms in the first year of life. METHODS: A total of 345 women were recruited in the first trimester of pregnancy and followed up with their children through the first year of life. Use of acetaminophen in pregnancy was determined by questionnaire and related to incidence of respiratory symptoms. RESULTS: Use of acetaminophen in middle to late but not early pregnancy was significantly related to wheezing (odd ratio, 1.8; 95% confidence interval, 1.1-3.0) and to wheezing that disturbed sleep (odds ratio, 2.1; 95% confidence interval, 1.1-3.8) in the first year of life after control for potential confounders. CONCLUSION: This study suggests that use of acetaminophen in middle to late but not early pregnancy may be related to respiratory symptoms in the first year of life. Additional follow-up will examine relationships of maternal and early childhood use of acetaminophen with incidence of asthma at ages 3 to 5 years, when asthma diagnosis is more firmly established.

Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: analysis from Phase Three of the ISAAC programme.Beasley R, Clayton T, Crane J, von Mutius E, Lai CK, Montefort S, Stewart A; ISAAC Phase Three Study Group.

Collaborators (96)

Aït-Khaled N, Anderson HR, Asher MI, Björkstén B, Brunekreef B, Crane J, Ellwood P, García-Marcos L, Foliaki S, Keil U, Lai CK, Mallol J, Robertson CF, Mitchell EA, Odhiambo J, Pearce N, Shah J, Stewart AW, Strachan D, Weiland SK, Weinmayr G, Williams H, Wong G, Asher MI, Clayton TO, Ellwood P, Mitchell EA, Howitt ME, Weyler J, de Freitas Souza L, Rennie D, Amarales L, Aguilar P, Cepeda AM, Aristizábal G, Ordoñez GA, Riikjärv MA, Zsigmond G, Rego S, Suresh Babu PS, Singh V, Jain KC, Sukumaran TU, Awasthi S, Joshi MK, Pherwani AV, Mantri SN, Salvi S, Sharma SK, Hanumante NM, Bhave S, Kartasasmita CB, Masjedi MR, Steriu A, Odajima H, Imanalieva C, Kudzyte J, Teh KH, Quah BS, Del-Río-Navarro BE, Barragán-Meijueiro M, García-Almaraz R, Baeza-Bacab M, Merida-Palacio JV, González-Díaz SN, Linares-Zapién FJ, Romero-Tapia S, Asher MI, Moyes C, Pattemore P, MacKay R, Onadeko BO, Cukier G, Lis G, Brêborowicz A, Câmara R, Rosado Pinto JE, Nunes C, Lopes dos Santos JM, Goh DY, Lee HB, López-Silvarrey Varela A, Carvajal-Urueña I, Busquets RM, González Díaz C, García-Marcos L, Garcia-Hernández G, Suárez-Varela MM, Al-Rawas O, Mohammad Y, Huang JL, Kao CC, Vichyanond P, Trakultivakorn M, Lapides MC, Aldrey O.

Medical Research Institute of New Zealand, Wellington, New Zealand.

BACKGROUND: Exposure to paracetamol during intrauterine life, childhood, and adult life may increase the risk of developing asthma. We studied 6-7-year-old children from Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) programme to investigate the association between paracetamol consumption and asthma. METHODS: As part of Phase Three of ISAAC, parents or guardians of children aged 6-7 years completed written questionnaires about symptoms of asthma, rhinoconjunctivitis, and eczema, and several risk factors, including the use of paracetamol for fever in the child’s first year of life and the frequency of paracetamol use in the past 12 months. The primary outcome variable was the odds ratio (OR) of asthma symptoms in these children associated with the use of paracetamol for fever in the first year of life, as calculated by logistic regression. FINDINGS: 205 487 children aged 6-7 years from 73 centres in 31 countries were included in the analysis. In the multivariate analyses, use of paracetamol for fever in the first year of life was associated with an increased risk of asthma symptoms when aged 6-7 years (OR 1.46 [95% CI 1.36-1.56]). Current use of paracetamol was associated with a dose-dependent increased risk of asthma symptoms (1.61 [1.46-1.77] and 3.23 [2.91-3.60] for medium and high use vs no use, respectively). Use of paracetamol was similarly associated with the risk of severe asthma symptoms, with population-attributable risks between 22% and 38%. Paracetamol use, both in the first year of life and in children aged 6-7 years, was also associated with an increased risk of symptoms of rhinoconjunctivitis and eczema. INTERPRETATION: Use of paracetamol in the first year of life and in later childhood, is associated with risk of asthma, rhinoconjunctivitis, and eczema at age 6 to 7 years. We suggest that exposure to paracetamol might be a risk factor for the development of asthma in childhood.

The relation between paracetamol use and asthma: a GA2LEN European case-control study.Shaheen S, Potts J, Gnatiuc L, Makowska J, Kowalski ML, Joos G, van Zele T, van Durme Y, De Rudder I, Wöhrl S, Godnic-Cvar J, Skadhauge L, Thomsen G, Zuberbier T, Bergmann KC, Heinzerling L, Gjomarkaj M, Bruno A, Pace E, Bonini S, Fokkens W, Weersink EJ, Loureiro C, Todo-Bom A, Villanueva CM, Sanjuas C, Zock JP, Janson C, Burney P; Selenium and Asthma Research Integration project; GA2LEN.

Collaborators (36)

Burney P, Phillips J, Potts J, Gnatiuc L, Shaheen S, Joos G, Van Cauwenberge P, van Zele T, Verbruggen K, van Durme Y, De Rudder I, Wöhrl S, Godnic-Cvar J, Salameh B, Skadhauge L, Thomsen G, Zuberbier T, Bergmann KC, Heinzerling L, Gjomarkaj M, Bruno A, Pace E, Bonini S, Bresciani M, Gramiccioni C, Fokkens W, Weersink EJ, Makowska J, Kowalski ML, Loureiro C, Todo-Bom A, Villanueva CM, Sanjuas C, Zock JP, Lundback B, Janson C.

National Heart and Lung Institute, Imperial College London, Emmanuel Kaye Building, Manresa Road, London SW3 6LR, UK.

Studies from the UK and USA suggest that frequent use of paracetamol (acetaminophen) may increase the risk of asthma, but data across Europe are lacking. As part of a multicentric case-control study organised by the Global Allergy and Asthma European Network (GA(2)LEN), it was examined whether or not frequent paracetamol use is associated with adult asthma across Europe. The network compared 521 cases with a diagnosis of asthma and reporting of asthma symptoms within the last 12 months with 507 controls with no diagnosis of asthma and no asthmatic symptoms within the last 12 months across 12 European centres. All cases and controls were selected from the same population, defined by age (20-45 yrs) and place of residence. In a random effects meta-analysis, weekly use of paracetamol, compared with less frequent use, was strongly positively associated with asthma after controlling for confounders. There was no evidence for heterogeneity across centres. No association was seen between use of other analgesics and asthma. These data add to the increasing and consistent epidemiological evidence implicating frequent paracetamol use in asthma in diverse populations.

Study of the relationship between acetaminophen and asthma in Mexican children aged 6 to 7 years in 3 Mexican cities using ISAAC methodology.Del-Rio-Navarro BE, Ito-Tsuchiya FM, Berber A, Zepeda-Ortega B, Sienra-Monge JJ, Garcia-Almaraz R, Baeza-Bacab M.

Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico.

OBJECTIVE: To establish the relationship between the use of acetaminophen and the frequency of asthma in Mexican children in 3 Mexican cities. METHODS: Ours was a multicenter, observational, descriptive, cross-sectional study. Patients from 6 to 7 years of age participating in Phase Three B of the ISAAC (International Study of Asthma and Allergies in Children) living in the north of Mexico City, Victoria City, and Merida were included. After adjusting for confounders, we calculated the odds ratios (OR) for the presence of wheezing ever, wheezing in the last 12 months, asthma ever, and the use of acetaminophen in the first year of life and during the last 12 months. RESULTS: The ORs for wheezing ever, wheezing in the last year, and asthma ever with respect to use of acetaminophen in the first year of life were not statistically significant (P > .05) in Mexico City, but they were significant in Victoria City (P < .05) and Merida (P < .05). The ORs (95% confidence intervals) for wheezing ever, wheezing in the last year, and asthma ever with respect to use of acetaminophen in the last year were 3.44 (2.96-4.0), 7.97 (5.89-10.78), and 6.10 (3.30-8.81) (P < .05) in Mexico City. Values forVictoria City were 1.36 (1.13-1.63), 3.80 (2.88-5.05), and 2.18(1.57-3.01) (P < .05). Those for Merida were 1.61 (1.40-1.85), 2.07 (1.73-2.48), and 1.53 (1.29-1.82) (P < .05). CONCLUSION: The use of acetaminophen is associated with the presence of wheezing and asthma in 3 different cities in Mexico.

Acetaminophen use and the symptoms of asthma, allergic rhinitis and eczema in children.Karimi M, Mirzaei M, Ahmadieh MH.

Department of Pediatrics, School of Medicine, Shahid Sadoughi University Of Medical Sciences and Health Services, Yazd, Iran.

Allergic diseases are frequent in children and their prevalence and severity differ in the different regions of the world. A number of studies have been performed to determine the factors which are effective in the incidence of these diseases. One of the drugs that might have a role in incidence or intensity of the symptoms of allergic diseases is Acetaminophen. In our survey conducted with standardized method (International Study of Asthma and Allergies in Childhood), 3000 children 6-7 years old and 3000 teenagers 13-14 years old were questioned regarding asthma, allergic rhinitis and eczema. The prevalence of ever wheezing in the children of 6-7 years old who took acetaminophen in the first year of their life was 11.3%, which is more than other group (Odds Ratio=1.54, 95% Confidence Interval: 1-2.38, P=0.049) and the prevalence of ever wheezing in older age group who have taken acetaminophen at least once in a month was 25.1% which is more than those taken less acetaminophen (OR=1.7, 95%CI=1.43-2.04, P=0.000). Moreover taking more acetaminophen during past 12 months led to more prevalence of night dry coughs and the symptoms of rhinitis in children 6-7 years old and eczema and rhinitis symptoms in the 13-14 years old. Our findings suggest that taking more acetaminophen may be associated with increasing allergic symptoms in children.

How many more friggin studies do we NEED? This stuff should not be given to babies.

Oh…look what else I found…

Simultaneous sudden infant death syndrome.Balci Y, Tok M, Kocaturk BK, Yenilmez C, Yirulmaz C.

Department of Forensic Medicine, Medical Faculty, Osmangazi University, Eskişehir, Turkey.

The simultaneous sudden deaths of twins rarely occur and therefore it has received limited attention in the medical literature. When the deaths of the twins meet the defined criteria for sudden infant death syndrome (SIDS) independently and take place within the same 24 h range it can be called as simultaneous SIDS (SSIDS). The case(s): Twin girls (3.5-month-old) were found dead by their mother in their crib, both in supine position. The infants were identical twins and delivered at a hospital by cesarean section. Both infants were healthy and did not have any serious medical history. Two days prior to the incident, the twins had received the second dose of oral polio, DPT and the first dose of hepatitis B vaccines and they had fever on the first day of the vaccination and been given teaspoonful of acetaminophen. Death scene investigation, judicial investigation, parental assessment, macroscopic and microscopic autopsy findings and the toxicological analysis did not yield any specific cause of death. The case(s) were referred to a supreme board composed of multidisciplinary medical professionals at the Institute of Forensic Medicine, Ministry of Justice, in Istanbul. The Board decided that the available data was consistent with SIDS. These SIDS case(s) are presented because twin SIDS are rare and this is the first time that a simultaneous twin SIDS have been reported in Turkey. Simultaneous SIDS cases have many implications regarding definition, diagnosis and medico-legal approach.

Geez…these babies were given a TEASPOON of acetaminophen???!!! A TEASPOON of acetaminophen is an OVERDOSE! DUH! They still ruled it as SIDS? GMAB

Anyone still think acetaminophen is a good thing to give to babies? Or shall I post some more evidence?

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